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1

Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses

Angela Clerk, Timothy E. Cullingford, Stephen J. Fuller, Alejandro Giraldo, Thomais Markou, Sampsa Pikkarainen, Peter H. Sugden

Journal:

Journal of Cellular Physiology

Year:

2007

Language:

english

File:

PDF, 299 KB

english, 2007

2

Dystrophin-related protein, utrophin, in normal and dystrophic human fetal skeletal muscle

Angela Clerk, Glenn E. Morris, Victor Dubowitz, Kay E. Davies, Caroline A. Sewry

Journal:

Journal of Molecular Histology

Year:

1993

Language:

english

File:

PDF, 775 KB

english, 1993

3

Dystrophin-related protein, utrophin, in normal and dystrophic human fetal skeletal muscle

Angela Clerk, Glenn E. Morris, Victor Dubowitz, Kay E. Davies, Caroline A. Sewry

Journal:

Journal of Molecular Histology

Year:

1993

Language:

english

File:

PDF, 775 KB

english, 1993

4

Cellular mechanisms of cardiac hypertrophy

P. H. Sugden, Angela Clerk

Journal:

Journal of Molecular Medicine

Year:

1998

Language:

english

File:

PDF, 297 KB

english, 1998

5

A Dystrophin-Immunoreactive Protein in Mammalian Brain

Angela Clerk, Francesco Muntoni, Peter N. Strong

Journal:

Journal of Neurochemistry

Year:

1993

Language:

english

File:

PDF, 2.21 MB

english, 1993

6

Kinases as therapeutic targets for heart failure

Vlahos, Chris J., McDowell, Susan A., Clerk, Angela

Journal:

Nature Reviews Drug Discovery

Year:

2003

Language:

english

File:

PDF, 742 KB

english, 2003

7

Oxidative Stress and Growth-Regulating Intracellular Signaling Pathways in Cardiac Myocytes

Sugden, Peter H., Clerk, Angela

Journal:

Antioxidants & Redox Signaling

Year:

2006

Language:

english

File:

PDF, 333 KB

english, 2006

8

Integration of protein kinase signaling pathways in cardiac myocytes: signaling to and from the extracellular signal-regulated kinases

Angela Clerk, Timothy J. Kemp, Joanne G. Harrison, Fong H. Pham, Peter H. Sugden

Journal:

Advances in Enzyme Regulation

Year:

2004

Language:

english

File:

PDF, 297 KB

english, 2004

9

Regulation of gene and protein expression in cardiac myocyte hypertrophy and apoptosis

Angela Clerk, Timothy E. Cullingford, Timothy J. Kemp, Robert A. Kennedy, Peter H. Sugden

Journal:

Advances in Enzyme Regulation

Year:

2005

Language:

english

File:

PDF, 406 KB

english, 2005

10

Chemotherapeutic agents and gene expression in cardiac myocytes

Angela Clerk, Alejandro Giraldo, Peter H. Sugden

Journal:

Advances in Enzyme Regulation

Year:

2007

Language:

english

File:

PDF, 208 KB

english, 2007

11

Endothelin-1 regulation of immediate early gene expression in cardiac myocytes: negative feedback regulation of interleukin 6 by Atf3 and Klf2

Angela Clerk, Timothy E. Cullingford, Stephen J. Fuller, Alejandro Giraldo, Peter H. Sugden

Journal:

Advances in Enzyme Regulation

Year:

2009

Language:

english

File:

PDF, 429 KB

english, 2009

12

Endothelin-1 promotes phosphorylation of CREB transcription factor in primary cultures of neonatal rat cardiac myocytes: implications for the regulation of c-jun expression

Joanne G Harrison, Peter H Sugden, Angela Clerk

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2004

Language:

english

File:

PDF, 555 KB

english, 2004

13

Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: Effects of endothelin-1, oxidative stress and cytokines

Timothy E. Cullingford, Matthew J. Butler, Andrew K. Marshall, El Li Tham, Peter H. Sugden, Angela Clerk

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2008

Language:

english

File:

PDF, 957 KB

english, 2008

14

Peptide growth factors signal differentially through protein kinase C to extracellular signal-regulated kinases in neonatal cardiomyocytes

Angela Clerk, Ioanna-Katerina S. Aggeli, Konstantina Stathopoulou, Peter H. Sugden

Journal:

Cellular Signalling

Year:

2006

Language:

english

File:

PDF, 432 KB

english, 2006

15

Glycogen synthase kinases 3α and 3β in cardiac myocytes: Regulation and consequences of their inhibition

Thomais Markou, Timothy E. Cullingford, Alejandro Giraldo, Sophie C. Weiss, Ali Alsafi, Stephen J. Fuller, Angela Clerk, Peter H. Sugden

Journal:

Cellular Signalling

Year:

2008

Language:

english

File:

PDF, 1.31 MB

english, 2008

16

Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: Activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors

Stephen J. Fuller, Sampsa Pikkarainen, El Li Tham, Timothy E. Cullingford, Jeffery D. Molkentin, Hauke Cornils, Alexander Hergovich, Brian A. Hemmings, Angela Clerk, Peter H. Sugden

Journal:

Cellular Signalling

Year:

2008

Language:

english

File:

PDF, 836 KB

english, 2008

17

Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active

Peter H. Sugden, Thomais Markou, Stephen J. Fuller, El Li Tham, Jeffery D. Molkentin, Hugh F. Paterson, Angela Clerk

Journal:

Cellular Signalling

Year:

2011

Language:

english

File:

PDF, 1.52 MB

english, 2011

18

Corrigendum to “Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active” [Cell Signal 23 (2011) 468–477]

Peter H. Sugden, Thomais Markou, Stephen J. Fuller, El Li Tham, Jeffery D. Molkentin, Hugh F. Paterson, Angela Clerk

Journal:

Cellular Signalling

Year:

2011

Language:

english

File:

PDF, 83 KB

english, 2011

19

Activation of protein kinase cascades in the heart by hypertrophic G protein–coupled receptor agonists

Angela Clerk, Peter H Sugden

Journal:

The American Journal of Cardiology

Year:

1999

Language:

english

File:

PDF, 130 KB

english, 1999

20

Regulation of cardiac myocyte cell death

Angela Clerk, Sharon M Cole, Timothy E Cullingford, Joanne G Harrison, Mika Jormakka, Donna M Valks

Journal:

Pharmacology & Therapeutics

Year:

2003

Language:

english

File:

PDF, 1.11 MB

english, 2003

21

Regulation of the ERK Subgroup of MAP Kinase Cascades Through G Protein-Coupled Receptors

Peter H Sugden, Angela Clerk

Journal:

Cellular Signalling

Year:

1997

Language:

english

File:

PDF, 1.15 MB

english, 1997

22

Activation of the Small GTP-binding Protein Ras in the Heart by Hypertrophic Agonists

Peter H Sugden, Angela Clerk

Journal:

Trends in Cardiovascular Medicine

Year:

2000

Language:

english

File:

PDF, 218 KB

english, 2000

23

Regulation of the cardiomyocyte transcriptomevstranslatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin

Thomais Markou, Andrew K Marshall, Timothy E Cullingford, El L Tham, Peter H Sugden, Angela Clerk

Journal:

Year:

2010

Language:

english

File:

PDF, 878 KB

english, 2010

24

Activation of c-Jun N-Terminal Kinases and p38-Mitogen-activated Protein Kinases in Human Heart Failure Secondary to Ischaemic Heart Disease

Stuart A. Cook, Peter H. Sugden, Angela Clerk

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1999

Language:

english

File:

PDF, 210 KB

english, 1999

25

Pro-inflammatory Cytokines Stimulate Mitogen-activated Protein Kinase Subfamilies, Increase Phosphorylation of c-Jun and ATF2 and Upregulate c-Jun Protein in Neonatal Rat Ventricular Myocytes

Angela Clerk, Joanne G Harrison, Carlin S Long, Peter H Sugden

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1999

Language:

english

File:

PDF, 631 KB

english, 1999

26

Death by Protein Kinase C Inhibitor: a Stressful Event

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2001

Language:

english

File:

PDF, 68 KB

english, 2001

27

Phenylephrine Promotes Phosphorylation of Bad in Cardiac Myocytes Through the Extracellular Signal-regulated Kinases 1/2 and Protein Kinase A

Donna M. Valks, Stuart A. Cook, Fong H. Pham, Paul R. Morrison, Angela Clerk, Peter H. Sugden

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2002

Language:

english

File:

PDF, 937 KB

english, 2002

28

Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1

Arne Yndestad, Andrew K. Marshall, Jonathan D. Hodgkinson, El Li Tham, Peter H. Sugden, Angela Clerk

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2010

Language:

english

File:

PDF, 1.37 MB

english, 2010

29

Phenylephrine and endothelin-1 upregulate connective tissue growth factor in neonatal rat cardiac myocytes

Timothy J Kemp, Ioanna-Katerina Aggeli, Peter H Sugden, Angela Clerk

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2004

Language:

english

File:

PDF, 270 KB

english, 2004

30

Effects of oxidative stress on the cardiac myocyte proteome: modifications to peroxiredoxins and small heat shock proteins

Tim E. Cullingford, Robin Wait, Angela Clerk, Peter H. Sugden

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2006

Language:

english

File:

PDF, 685 KB

english, 2006

31

Using U0126 to dissect the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes

Robert A. Kennedy, Timothy J. Kemp, Peter H. Sugden, Angela Clerk

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2006

Language:

english

File:

PDF, 593 KB

english, 2006

32

Ras: The stress and the strain

Angela Clerk, Peter H. Sugden

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2006

Language:

english

File:

PDF, 267 KB

english, 2006

33

Regulation of the expression of ATF3 in cardiac myocytes in response to hypertrophic and apoptotic stimulation

Alejandro Giraldo, Sampsa Pikkarainen, Peter H. Sugden, Angela Clerk

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2007

Language:

english

File:

PDF, 47 KB

english, 2007

34

Are transgenic mice the ‘alkahest’ to understanding myocardial hypertrophy and failure?

Stuart A. Cook, Angela Clerk, Peter H. Sugden

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2009

Language:

english

File:

PDF, 612 KB

english, 2009

35

Changes in gene expression induced by H2O2 in cardiac myocytes

Timothy J. Kemp, Helen C. Causton, Angela Clerk

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 170 KB

english, 2003

36

Activation of p21-activated protein kinase α (αPAK) by hyperosmotic shock in neonatal ventricular myocytes

Angela Clerk, Peter H Sugden

Journal:

Year:

1997

Language:

english

File:

PDF, 378 KB

english, 1997

37

The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs)

Angela Clerk, Peter H Sugden

Journal:

Year:

1998

Language:

english

File:

PDF, 193 KB

english, 1998

38

Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by adenosine in the perfused rat heart

Syed E.A. Haq, Angela Clerk, Peter H. Sugden

Journal:

Year:

1998

Language:

english

File:

PDF, 196 KB

english, 1998

39

The radical balance between life and death

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2003

Language:

english

File:

PDF, 63 KB

english, 2003

40

Regulation of mitogen-activated protein kinase cascades in the heart

Peter H Sugden, Angela Clerk

Journal:

Advances in Enzyme Regulation

Year:

1998

Language:

english

File:

PDF, 268 KB

english, 1998

41

Regulation of Phospholipases C and D in Rat Ventricular Myocytes: Stimulation by Endothelin-1, Bradykinin and Phenylephrine

Angela Clerk, Peter H. Sugden

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1997

Language:

english

File:

PDF, 378 KB

english, 1997

42

The early transcriptomic response to interleukin 1β and interleukin 33 in rat neonatal cardiomyocytes

Barrett, Oliver P.T., Yndestad, Arne, Marshall, Andrew K., Sugden, Peter H., Clerk, Angela

Journal:

Year:

2013

Language:

english

File:

PDF, 375 KB

english, 2013

43

Characterisation of dystrophin in fetuses at risk for Duchenne muscular dystrophy

Angela Clerk, Caroline A. Sewry, Victor Dubowitz, Peter N. Strong

Journal:

Journal of the Neurological Sciences

Year:

1992

Language:

english

File:

PDF, 1.85 MB

english, 1992

44

Muscular weakness in the mdx mouse

Francesco Muntoni, Anna Mateddu, Francesca Marchei, Angela Clerk, Gino Serra

Journal:

Journal of the Neurological Sciences

Year:

1993

Language:

english

File:

PDF, 1.82 MB

english, 1993

45

Regulation of cardiac myocyte protein synthesis through phosphatidylinositol 3′ kinase and protein kinase B

Fong H. Pham, Sharon M. Cole, Angela Clerk

Journal:

Advances in Enzyme Regulation

Year:

2001

Language:

english

File:

PDF, 247 KB

english, 2001

46

Stimulation of the p38 Mitogen-Activated Protein Kinase Pathway in Neonatal Rat Ventricular Myocytes by the G Protein-Coupled Receptor Agonists, Endothelin-1 and Phenylephrine: A Role in Cardiac Myocyte Hypertrophy?

Angela Clerk, Ashour Michael and Peter H. Sugden

Journal:

The Journal of Cell Biology

Year:

1998

Language:

english

File:

PDF, 3.57 MB

english, 1998

47

Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes

Clerk, Angela, Sugden, Peter H

Journal:

Biochemistry and Cell Biology

Year:

2004

Language:

english

File:

PDF, 131 KB

english, 2004

48

Targeting myocardial remodelling to develop novel therapies for heart failure

Tarone, Guido, Balligand, Jean-Luc, Bauersachs, Johann, Clerk, Angela, De Windt, Leon, Heymans, Stephane, Hilfiker-Kleiner, Denise, Hirsch, Emilio, Iaccarino, Guido, Knöll, Ralph, Leite-Moreira, Adeli

Journal:

European Journal of Heart Failure

Year:

2014

Language:

english

File:

PDF, 857 KB

english, 2014

49

ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models

Leite-Moreira, Adelino F., Lourenço, André P., Balligand, Jean-Luc, Bauersachs, Johann, Clerk, Angela, De Windt, Leon J., Heymans, Stephane, Hilfiker-Kleiner, Denise, Hirsch, Emilio, Iaccarino, Guido,

Journal:

European Journal of Heart Failure

Year:

2014

Language:

english

File:

PDF, 339 KB

english, 2014

50

Endothelin Signalling in the Cardiac Myocyte and its Pathophysiological Relevance

Sugden, Peter, Clerk, Angela

Journal:

Current Vascular Pharmacology

Year:

2005

Language:

english

File:

PDF, 112 KB

english, 2005